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By John R. Baker, Ralph Muller, David Rollinson

ISBN-10: 0120317583

ISBN-13: 9780120317585

The Advances in Parasitology sequence includes in-depth reports on present themes of curiosity in modern parasitology. It comprises clinical stories on parasites of significant impression, comparable to trypanosomiasis and scabies, and extra conventional components, akin to zoology, taxonomy, and existence historical past, which form present considering and purposes. * sequence has the second one maximum ISI influence consider the parasitology staff! (4.818 in 2002) * individuals are foreign specialists within the box

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Both amastigotes and intermediate stages in the transformation between promastigotes and amastigotes (from 12 h post-phagocytosis of metacyclic promastigotes) can internalize molecules involved in the class II-restricted Ag presentation. , 2001). Of course, it is tempting to see in this phenomenon an escape mechanism from the adaptive immune response but the formal demonstration of such a possibility remains to be provided. Nevertheless, it is likely that internalization of PV membrane molecules by Leishmania is a means evolved by the parasites to modulate their intracellular niche.

This defect is apparently linked to the down regulation of CCR7 and could explain why, in spleens of mice with chronic L. , 2002). In this case, however, CCR7 down regulation and the subsequent impaired migration of DCs is apparently not due to the direct action of parasite molecules but due to the effect of cytokines abundantly produced during L. donovani infection, namely TNF- and IL-10 (Figure 9; see colour plate section). In apparent contrast with the results of the previous study, those of De Trez et al.

Whereas in vitro experiments have clearly demonstrated that tumour necrosis factor (TNF) can play this potentiating role, some in vivo experiments have led some authors to propose another function for this cytokine during L. major infections. , 2003). , 1996). Interestingly, this pathway appears to be altered in L. , 2003). -C. ANTOINE ET AL. ILIL-10 IL-6 ILIL-4 ILIFNIFN-α/β ILIL-13 amastigotes NADPH NADP + H + + e- killed amastigotes H2O2 O2 apoptosis of infected MΦs TGFTGF-β O2OH- parasite molecules involved in the protection towards leishmanicidal mechanisms: LPG, PPG, GIPLs, trypanothione, SOD, catalase Fas FasL L-arginine + O2 effector T lymphocyte CD40L NO RNI ?

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Advances in Parasitology, Vol. 58 by John R. Baker, Ralph Muller, David Rollinson

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